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Hypericin
Hypericin C30H16O8 PubChem.
National Library of Medicine NCBI National Center for Biotechnology Information. OPEN CHEMISTRY DATABASE. This application requires Javascript. Please turn on Javascript in order to use this application. Data Citation Guidelines. National Center for Biotechnology Information, U.S. National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20894, USA.
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Hypericin.
Hypericin as a photosensitizer has been shown to induce apoptosis and necrosis in cancer cells using photodynamic therapy Agostinis 2002. In laboratory studies, hypericin has demonstrated anti-retroviral activity using a method of action that does not rely on inhibition, inactivation, or modification of reverse transcriptase.
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Hypericin an overview ScienceDirect Topics. ScienceDirect. Elsevier. RELX Group.
Administration per os of 250, 750, and 1500, g of hypericin and 526, 1578, and 3156, g of pseudohypericin resulted in median peak levels C max of 1.3, 7.2, and 16.6 g/L plasma for hypericin and 3.4, 12.1, and 29.7 g/L plasma pseudohypericin, respectively.
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Hypericin-the facts about a controversial agent. PubMed NCBI.
In the last three decades, hypericin has also become the subject of intensive biochemical research and is proving to be a multifunctional agent in drug and medicinal applications. Recent studies report antidepressive, antineoplastic, antitumor and antiviral human immunodeficiency and hepatitis C virus activities of hypericin; intriguing information even if confirmation of data is incomplete and mechanisms of these activities still remain largely unexplained.
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PDF Hypericin The Facts About a Controversial Agent.
Show full abstract Hypericin contents of the cells treated with both NO and H2O 2 are significantly higher than those of the cells treated with NO alone, although H2O2 per se has no effects on hypericin production of the cells, which suggests the synergistic action between H 2O2 and NO on hypericin production.
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Long-term effects of St. John's' wort and hypericin on monoamine levels in rat hypothalamus and hippocampus. PubMed NCBI.
We used a high-performance liquid chromatography system to examine the effects of short-term 2 weeks and long-term 8 weeks administration of imipramine, Hypericum extract or hypericin on regional levels of serotonin 5-HT, norepinephrine, dopamine and their metabolites in the rat brain.
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The Anticancer Activity of Hypericin in Photodynamic Therapy OMICS International.
Researchers still need to explore the anticancer effects of hypericin during PDT on various other existing cancers, to find the suitable laser parameters in combination with the complementary hypericin concentrations that can be used for the treatment of primary and secondary tumors.
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Hypericin an overview ScienceDirect Topics. ScienceDirect. Elsevier. RELX Group.
Administration per os of 250, 750, and 1500, g of hypericin and 526, 1578, and 3156, g of pseudohypericin resulted in median peak levels C max of 1.3, 7.2, and 16.6 g/L plasma for hypericin and 3.4, 12.1, and 29.7 g/L plasma pseudohypericin, respectively.
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Hypericin CAS 548-04-9 SCBT Santa Cruz Biotechnology.
Hypericin is also noted to possess antiviral activity and is of interest in HIV studies. Hypericin is of interest in studies investigating photodynamic treatment of tumors and has been reported to be cytotoxic to some tumor cell lines when Hypericin is photoactivated.
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St. Johns Wort Hypericin aidsinfonet.org The AIDS InfoNet.
Patients were given intravenous doses of purified hypericin. The study was stopped when every white-skinned patient in the trial became very sensitive to light. They developed skin rashes and some could not go outside until after they stopped taking hypericin.

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