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Hypericin
Hypericin C30H16O8 PubChem.
National Library of Medicine NCBI National Center for Biotechnology Information. OPEN CHEMISTRY DATABASE. This application requires Javascript. Please turn on Javascript in order to use this application. Data Citation Guidelines. National Center for Biotechnology Information, U.S. National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20894, USA.
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Hypericin C30H16O8 ChemSpider.
71113161822-he, xahydroxy-524-dime, thyloctacyclo13.11 1.1210.038.0425, 01927.02126.014, 28octacosa-1357, 101214281517, 1927212325-tr, idecaene-920-dione., Hypericin from Hype ricum perforatumCy clo-Werrol; Hyperic um red. InChI1/C30H16O8/c1 7-3-93119-23-15 716-824-103220 241628-26-1812 346-1436222630 203817-11335-1 3352129193725 17272328/h3-63, 1-36H1-2H., Phenanthro11098, opqraperylene-71, 4-dione134681, 3-hexahydroxy-1011, dimethyl, stereoi somer. johns wort extr act, 41, powder.
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Pharmacokinetics, Safety, and Antiviral Effects of Hypericin, a Derivative of St. John's' Wort Plant, in Patients with Chronic Hepatitis C Virus Infection Antimicrobial Agents and Chemotherapy.
The gradient high-performance liquid chromatography methodology employed for the analysis of hypericin was adequate to allow quantitation of any hypericin-derived metabolites, as the assay used the visible absorption maximum of the hypericin molecule. However, no discernible peaks other than the hypericin molecule were detected over all of the study monitoring time points.
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Hypericin Wikipedia.
Hypericin derives from polyketides cyclisation. The biosynthesis of hypericins is in the polyketide pathway where an octaketide chain goes through processes of cylizations and decarboxylations form emodin anthrone which are believed to be the precursors of hypericin. Oxidization reactions yield protoforms which then are converted into hypericin and pseudohypericin.
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Weekly Dose: St John's' Wort, the flower that can treat depression.
While individual key constituents have been identified as hypericin a naturally occurring substance with a few different applications including antidepressive, pseudohypericin and hyperforin a phytochemical produced in some plants, collectively they exert a number of pharmacological effects including antidepressant activity.
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Hypericin an overview ScienceDirect Topics. ScienceDirect. Elsevier. RELX Group.
Administration per os of 250, 750, and 1500, g of hypericin and 526, 1578, and 3156, g of pseudohypericin resulted in median peak levels C max of 1.3, 7.2, and 16.6 g/L plasma for hypericin and 3.4, 12.1, and 29.7 g/L plasma pseudohypericin, respectively.
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Frontiers Hypericin in the Light and in the Dark: Two Sides of the Same Coin Plant Science.
The instilled hypericin accumulated selectively in the bladder urothelial tumors and the normal urothelium in a ratio of 121, but no hypericin was detected in normal bladder submucosa and muscle layers, which is an important factor to avoid underlying tissue damage.
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Hypericin-the facts about a controversial agent. PubMed NCBI.
Recent studies report antidepressive, antineoplastic, antitumor and antiviral human immunodeficiency and hepatitis C virus activities of hypericin; intriguing information even if confirmation of data is incomplete and mechanisms of these activities still remain largely unexplained. In other contemporary studies, screening hypericin for inhibitory effects on various pharmaceutically important enzymes such as MAO monoaminoxidase, PKC protein kinase C, dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP cytochrome P450, has yielded results supporting therapeutic potential.
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Hypericin an overview ScienceDirect Topics. ScienceDirect. Elsevier. RELX Group.
Administration per os of 250, 750, and 1500, g of hypericin and 526, 1578, and 3156, g of pseudohypericin resulted in median peak levels C max of 1.3, 7.2, and 16.6 g/L plasma for hypericin and 3.4, 12.1, and 29.7 g/L plasma pseudohypericin, respectively.
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Hypericin Supplier CAS 548-04-9 Tocris Bioscience.
Lenard et al 1993 Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses using hypericin and rose bengal: inhibition of fusion and syncytia formation. 90 158 PMID: 7678335. If you know of a relevant reference for Hypericin, please let us know.
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