Results for Hypericin

Hypericin C30H16O8 PubChem.
National Library of Medicine NCBI National Center for Biotechnology Information. OPEN CHEMISTRY DATABASE. This application requires Javascript. Please turn on Javascript in order to use this application. Data Citation Guidelines. National Center for Biotechnology Information, U.S. National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20894, USA.
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The Anticancer Activity of Hypericin in Photodynamic Therapy OMICS International.
A study shown that HeLa cells treated with 80 250 nmol/l of hypericin and a light dose of 4 J/cm 2 induced apoptosis, and an increased hypericin concentration 1 mol/l with the same light dose of 4 J/cm 2 induced necrosis.
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Long-term effects of St. John's' wort and hypericin on monoamine levels in rat hypothalamus and hippocampus. PubMed NCBI.
We used a high-performance liquid chromatography system to examine the effects of short-term 2 weeks and long-term 8 weeks administration of imipramine, Hypericum extract or hypericin on regional levels of serotonin 5-HT, norepinephrine, dopamine and their metabolites in the rat brain.
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Frontiers Hypericin in the Light and in the Dark: Two Sides of the Same Coin Plant Science.
The instilled hypericin accumulated selectively in the bladder urothelial tumors and the normal urothelium in a ratio of 121, but no hypericin was detected in normal bladder submucosa and muscle layers, which is an important factor to avoid underlying tissue damage.
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Hypericin an overview ScienceDirect Topics. ScienceDirect. Elsevier. RELX Group.
Administration per os of 250, 750, and 1500, g of hypericin and 526, 1578, and 3156, g of pseudohypericin resulted in median peak levels C max of 1.3, 7.2, and 16.6 g/L plasma for hypericin and 3.4, 12.1, and 29.7 g/L plasma pseudohypericin, respectively.
Hypericin CAS 548-04-9 SCBT Santa Cruz Biotechnology.
Hypericin is also noted to possess antiviral activity and is of interest in HIV studies. Hypericin is of interest in studies investigating photodynamic treatment of tumors and has been reported to be cytotoxic to some tumor cell lines when Hypericin is photoactivated.
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Hypericin-the facts about a controversial agent. PubMed NCBI.
In the last three decades, hypericin has also become the subject of intensive biochemical research and is proving to be a multifunctional agent in drug and medicinal applications. Recent studies report antidepressive, antineoplastic, antitumor and antiviral human immunodeficiency and hepatitis C virus activities of hypericin; intriguing information even if confirmation of data is incomplete and mechanisms of these activities still remain largely unexplained.
Hypericin Wikipedia.
Hypericin derives from polyketides cyclisation. The biosynthesis of hypericins is in the polyketide pathway where an octaketide chain goes through processes of cylizations and decarboxylations form emodin anthrone which are believed to be the precursors of hypericin. Oxidization reactions yield protoforms which then are converted into hypericin and pseudohypericin.
PDF Hypericin The Facts About a Controversial Agent.
Alizarin, quinalizarin, rhein, hypericin, and protohypericin, but also other anthraquinones derivatives as emodin, aloe-emodin, emodin anthrone, emodin bianthrone chrysophanic acid, and hypericin showed activity against several strains of human or animal viruses, clearly distinguishable from cytotoxic effects on cells Barnard et al.
Hypericin an overview ScienceDirect Topics. ScienceDirect. Elsevier. RELX Group.
Patients with SCC were given 40 to 100 g hypericin intralesionally three to five times per week for 2 to 4 weeks; patients with BCC were treated with 40 to 200 g hypericin three to five times per week for 2 to 6 weeks.

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